Detection of complement activation using monoclonal antibodies against C3d

During complement activation the C3 protein is cleaved, and C3 activation fragments are covalently fixed to tissues. Tissue-bound C3 fragments are a durable biomarker of tissue inflammation, and these fragments have been exploited as addressable binding ligands for targeted therapeutics and diagnost...

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Bibliografiske detaljer
Main Authors: Thurman, Joshua M., Kulik, Liudmila, Orth, Heather, Wong, Maria, Renner, Brandon, Sargsyan, Siranush A., Mitchell, Lynne M., Hourcade, Dennis E., Hannan, Jonathan P., Kovacs, James M., Coughlin, Beth, Woodell, Alex S., Pickering, Matthew C., Rohrer, Bärbel, Holers, V. Michael
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2013
Fag:
Technical Advance
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3635726/
https://ncbi.nlm.nih.gov/pubmed/23619360
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI65861
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