Oxidative Stress Sensitizes Retinal Pigmented Epithelial (RPE) Cells to Complement-mediated Injury in a Natural Antibody-, Lectin Pathway-, and Phospholipid Epitope-dependent Manner

Uncontrolled activation of the alternative complement pathway (AP) is thought to be associated with age-related macular degeneration. Previously, we have shown that in retinal pigmented epithelial (RPE) monolayers, oxidative stress reduced complement inhibition on the cell surface, resulting in subl...

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Main Authors: Joseph, Kusumam, Kulik, Liudmila, Coughlin, Beth, Kunchithapautham, Kannan, Bandyopadhyay, Mausumi, Thiel, Steffen, Thielens, Nicole M., Holers, V. Michael, Rohrer, Bärbel
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2013
Teme:
Immunology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3642321/
https://ncbi.nlm.nih.gov/pubmed/23493397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.421891
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