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Assessing mRNA Translation: Deep Sequencing of Ribosome Footprints
A translating ribosome protects a discrete fragment of ∼30 nt on its mRNA template from nuclease digestion [Steitz, JA, (1969) Nature 224, 957]. Ribosome profiling determines the positions of active ribosomes on cellular mRNA by deep sequencing the ribosome-protected mRNA fragments [Ingolia, NT et a...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Association of Biomolecular Resource Facilities
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3635272/ |
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