RiboDiff: detecting changes of mRNA translation efficiency from ribosome footprints

MOTIVATION: Deep sequencing based ribosome footprint profiling can provide novel insights into the regulatory mechanisms of protein translation. However, the observed ribosome profile is fundamentally confounded by transcriptional activity. In order to decipher principles of translation regulation,...

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Publicat a:Bioinformatics
Autors principals: Zhong, Yi, Karaletsos, Theofanis, Drewe, Philipp, Sreedharan, Vipin T, Kuo, David, Singh, Kamini, Wendel, Hans-Guido, Rätsch, Gunnar
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2017
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Applications Notes
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5198522/
https://ncbi.nlm.nih.gov/pubmed/27634950
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/bioinformatics/btw585
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