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RiboDiff: detecting changes of mRNA translation efficiency from ribosome footprints

MOTIVATION: Deep sequencing based ribosome footprint profiling can provide novel insights into the regulatory mechanisms of protein translation. However, the observed ribosome profile is fundamentally confounded by transcriptional activity. In order to decipher principles of translation regulation,...

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Detalhes bibliográficos
Publicado no:Bioinformatics
Main Authors: Zhong, Yi, Karaletsos, Theofanis, Drewe, Philipp, Sreedharan, Vipin T, Kuo, David, Singh, Kamini, Wendel, Hans-Guido, Rätsch, Gunnar
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5198522/
https://ncbi.nlm.nih.gov/pubmed/27634950
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/bioinformatics/btw585
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