Organization and genesis of dihydrofolate reductase amplicons in the genome of a methotrexate-resistant Chinese hamster ovary cell line.

We have recently isolated overlapping recombinant cosmids that represent the equivalent of two complete dihydrofolate reductase (dhfr) amplicon types from the methotrexate-resistant Chinese hamster ovary (CHO) cell line CHOC 400. In the work described in this report, we used pulse-field gradient gel...

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Veröffentlicht in:	Mol Cell Biol
Hauptverfasser:	Ma, C, Looney, J E, Leu, T H, Hamlin, J L
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Taylor & Francis 1988
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC363429/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2841578/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.8.6.2316-2327.1988
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