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Comparative cellular pharmacokinetics and pharmacodynamics of siRNA delivery by SPANosomes and by cationic liposomes

Mechanistic understanding of intracellular trafficking is important for the development of small interfering RNA (siRNA) delivery vehicles. Here, we describe a novel methodology to quantitatively analyze nanocarrier-mediated disposition of siRNA. Cellular uptake and cytoplasmic release of siRNA over...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Zhou, Chenguang, Zhang, Yue, Yu, Bo, Phelps, Mitch A., Lee, L. James, Lee, Robert J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3633702/
https://ncbi.nlm.nih.gov/pubmed/23117046
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nano.2012.10.002
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