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Comparative cellular pharmacokinetics and pharmacodynamics of siRNA delivery by SPANosomes and by cationic liposomes

Mechanistic understanding of intracellular trafficking is important for the development of small interfering RNA (siRNA) delivery vehicles. Here, we describe a novel methodology to quantitatively analyze nanocarrier-mediated disposition of siRNA. Cellular uptake and cytoplasmic release of siRNA over...

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Autori principali: Zhou, Chenguang, Zhang, Yue, Yu, Bo, Phelps, Mitch A., Lee, L. James, Lee, Robert J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3633702/
https://ncbi.nlm.nih.gov/pubmed/23117046
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nano.2012.10.002
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