Comparative cellular pharmacokinetics and pharmacodynamics of siRNA delivery by SPANosomes and by cationic liposomes

Mechanistic understanding of intracellular trafficking is important for the development of small interfering RNA (siRNA) delivery vehicles. Here, we describe a novel methodology to quantitatively analyze nanocarrier-mediated disposition of siRNA. Cellular uptake and cytoplasmic release of siRNA over...

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Bibliografiske detaljer
Main Authors: Zhou, Chenguang, Zhang, Yue, Yu, Bo, Phelps, Mitch A., Lee, L. James, Lee, Robert J.
Format: Artigo
Sprog:Inglês
Udgivet: 2012
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3633702/
https://ncbi.nlm.nih.gov/pubmed/23117046
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nano.2012.10.002
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