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Transcription factor Foxp1 exerts essential cell-intrinsic regulation of the quiescence of naive T cells
The molecular mechanisms that underlie T cell quiescence are poorly understood. Here we report that mature naive CD8(+) T cells lacking the transcription factor Foxp1 gained effector phenotype and function and proliferated directly in response to interleukin 7 (IL-7) in vitro. Foxp1 repressed expres...
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| Main Authors: | , , , , , |
|---|---|
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2011
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3631322/ https://ncbi.nlm.nih.gov/pubmed/21532575 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.2034 |
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