VISTA is a checkpoint regulator for naïve T cell quiescence and peripheral tolerance

Negative checkpoint regulators (NCRs) temper the T cell immune response to self-antigens and limit the development of autoimmunity. Unlike all other NCRs that are expressed on activated T lymphocytes, V-type immunoglobulin domain-containing suppressor of T-cell activation (VISTA) is expressed on naï...

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Pubblicato in:Science
Autori principali: ElTanbouly, Mohamed A., Zhao, Yanding, Nowak, Elizabeth, Li, Jiannan, Schaafsma, Evelien, Le Mercier, Isabelle, Ceeraz, Sabrina, Lines, J. Louise, Peng, Changwei, Carriere, Catherine, Huang, Xin, Day, Maria, Koehn, Brent, Lee, Sam W., Morales, Milagros Silva, Hogquist, Kristin A., Jameson, Stephen C., Mueller, Daniel, Rothstein, Jay, Blazar, Bruce R., Cheng, Chao, Noelle, Randolph J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7391053/
https://ncbi.nlm.nih.gov/pubmed/31949051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aay0524
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