VISTA is a checkpoint regulator for naïve T cell quiescence and peripheral tolerance

Negative checkpoint regulators (NCRs) temper the T cell immune response to self-antigens and limit the development of autoimmunity. Unlike all other NCRs that are expressed on activated T lymphocytes, V-type immunoglobulin domain-containing suppressor of T-cell activation (VISTA) is expressed on naï...

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Publicat a:Science
Autors principals: ElTanbouly, Mohamed A., Zhao, Yanding, Nowak, Elizabeth, Li, Jiannan, Schaafsma, Evelien, Le Mercier, Isabelle, Ceeraz, Sabrina, Lines, J. Louise, Peng, Changwei, Carriere, Catherine, Huang, Xin, Day, Maria, Koehn, Brent, Lee, Sam W., Morales, Milagros Silva, Hogquist, Kristin A., Jameson, Stephen C., Mueller, Daniel, Rothstein, Jay, Blazar, Bruce R., Cheng, Chao, Noelle, Randolph J.
Format: Artigo
Idioma:Inglês
Publicat: 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7391053/
https://ncbi.nlm.nih.gov/pubmed/31949051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aay0524
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