The transcription factor Foxp1 is a critical negative regulator of the differentiation of follicular helper T cells

CD4(+) follicular helper T cells (T(FH) cells) are essential for germinal center (GC) responses and long-lived antibody responses. Here we report that naive CD4(+) T cells deficient in the transcription factor Foxp1 ‘preferentially’ differentiated into T(FH) cells, which resulted in substantially en...

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Hauptverfasser: Wang, Haikun, Geng, Jianlin, Wen, Xiaomin, Bi, Enguang, Kossenkov, Andrew V, Wolf, Amaya I, Tas, Jeroen, Choi, Youn Soo, Takata, Hiroshi, Day, Timothy J, Chang, Li-Yuan, Sprout, Stephanie L, Becker, Emily K, Willen, Jessica, Tian, Lifeng, Wang, Xinxin, Xiao, Changchun, Jiang, Ping, Crotty, Shane, Victora, Gabriel D, Showe, Louise C, Tucker, Haley O, Erikson, Jan, Hu, Hui
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4142638/
https://ncbi.nlm.nih.gov/pubmed/24859450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.2890
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