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Foxp1 controls naive CD8(+) T cell quiescence by simultaneously repressing key pathways in cellular metabolism and cell cycle progression
Previously we have shown that transcription factor Foxp1 plays an essential role in maintaining naive T cell quiescence; in the absence of Foxp1, mature naive CD8(+) T cells proliferate in direct response to homeostatic cytokine IL-7. Here we report that the deletion of Foxp1 in naive CD8(+) T cells...
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| Publicado no: | J Immunol |
|---|---|
| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4868629/ https://ncbi.nlm.nih.gov/pubmed/27001958 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1501896 |
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