Activated RhoA Is a Positive Feedback Regulator of the Lbc Family of Rho Guanine Nucleotide Exchange Factor Proteins

The monomeric Rho GTPases are essential for cellular regulation including cell architecture and movement. A direct mechanism for hormonal regulation of the RhoA-type GTPases is their modulation by the G(12) and G(13) proteins via RH (RGS homology) containing RhoGEFs. In addition to the interaction o...

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Autors principals: Medina, Frank, Carter, Angela M., Dada, Olugbenga, Gutowski, Stephen, Hadas, Jana, Chen, Zhe, Sternweis, Paul C.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2013
Matèries:
Signal Transduction
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3630898/
https://ncbi.nlm.nih.gov/pubmed/23493395
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.450056
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