The Lbc Rho Guanine Nucleotide Exchange Factor/α-Catulin Axis Functions in Serotonin-induced Vascular Smooth Muscle Cell Mitogenesis and RhoA/ROCK Activation

Serotonin (5-hydroxytryptamine, 5-HT) is mitogenic for several cell types including pulmonary arterial smooth muscle cells (PASMC), and is associated with the abnormal vascular smooth muscle remodeling that occurs in pulmonary arterial hypertension. RhoA/Rho kinase (ROCK) function is required for 5-...

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Autors principals: Bear, Michael D., Li, Min, Liu, Yinglin, Giel-Moloney, Maryann A., Fanburg, Barry L., Toksoz, Deniz
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2010
Matèries:
Signal Transduction
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2963423/
https://ncbi.nlm.nih.gov/pubmed/20696764
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.062513
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