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Use of Ion Mobility and Fragment Ions to Increase Coverage in Hydrogen-Deuterium Exchange

Peptide signals in H/D exchange mass spectrometry experiments are often overlapping on the m/z scale due to the nonspecific digestion, fast chromatographic conditions, and cold temperatures required to preserve the deuterium label. Co-eluting peptides which are well resolved when undeuterated can ov...

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Bibliografski detalji
Glavni autori: Stapels, Martha, Eggertson, Michael, Wales, Thomas, Engen, John, Fadgen, Keith
Format: Artigo
Jezik:Inglês
Izdano: Association of Biomolecular Resource Facilities 2012
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3630638/
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