Dual Inhibition of Endocannabinoid Catabolic Enzymes Produces Enhanced Antiwithdrawal Effects in Morphine-Dependent Mice

Inhibition of the endocannabinoid catabolic enzymes, monoacylglycerol lipase (MAGL) or fatty acid amide hydrolase (FAAH) attenuates naloxone-precipitated opioid withdrawal signs in mice via activation of CB(1) receptors. Complete FAAH inhibition blocks only a subset of withdrawal signs, whereas comp...

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Detalhes bibliográficos
Main Authors: Ramesh, Divya, Gamage, Thomas F, Vanuytsel, Tim, Owens, Robert A, Abdullah, Rehab A, Niphakis, Micah J, Shea-Donohue, Terez, Cravatt, Benjamin F, Lichtman, Aron H
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2013
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3629394/
https://ncbi.nlm.nih.gov/pubmed/23303065
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2012.269
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