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Dual Inhibition of Endocannabinoid Catabolic Enzymes Produces Enhanced Antiwithdrawal Effects in Morphine-Dependent Mice
Inhibition of the endocannabinoid catabolic enzymes, monoacylglycerol lipase (MAGL) or fatty acid amide hydrolase (FAAH) attenuates naloxone-precipitated opioid withdrawal signs in mice via activation of CB(1) receptors. Complete FAAH inhibition blocks only a subset of withdrawal signs, whereas comp...
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| Autors principals: | , , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Nature Publishing Group
2013
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3629394/ https://ncbi.nlm.nih.gov/pubmed/23303065 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2012.269 |
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