Anti-CD70 Immunocytokines for Exploitation of Interferon-γ-Induced RIP1-Dependent Necrosis in Renal Cell Carcinoma

Metastatic renal cell carcinoma (RCC) is an incurable disease in clear need of new therapeutic interventions. In early-phase clinical trials, the cytokine IFN-γ showed promise as a biotherapeutic for advanced RCC, but subsequent trials were less promising. These trials, however, focused on the indir...

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Bibliographic Details
Main Authors: Chen, Peirong, Nogusa, Shoko, Thapa, Roshan J., Shaller, Calvin, Simmons, Heidi, Peri, Suraj, Adams, Gregory P., Balachandran, Siddharth
Format: Artigo
Language:Inglês
Published: Public Library of Science 2013
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3629199/
https://ncbi.nlm.nih.gov/pubmed/23613854
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0061446
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