A Novel Small Compound SH-2251 Suppresses Th2 Cell-Dependent Airway Inflammation through Selective Modulation of Chromatin Status at the Il5 Gene Locus

IL-5 is a key cytokine that plays an important role in the development of pathological conditions in allergic inflammation. Identifying strategies to inhibit IL-5 production is important in order to establish new therapies for treating allergic inflammation. We found that SH-2251, a novel thioamide-...

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Détails bibliographiques
Auteurs principaux: Suzuki, Junpei, Kuwahara, Makoto, Tofukuji, Soichi, Imamura, Masashi, Kato, Fuminori, Nakayama, Toshinori, Ohara, Osamu, Yamashita, Masakatsu
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2013
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3628909/
https://ncbi.nlm.nih.gov/pubmed/23613936
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0061785
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