Lifetime imaging of a fluorescent protein sensor reveals surprising stability of ER thiol redox

Interfering with disulfide bond formation impedes protein folding and promotes endoplasmic reticulum (ER) stress. Due to limitations in measurement techniques, the relationships of altered thiol redox and ER stress have been difficult to assess. We report that fluorescent lifetime measurements circu...

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Hlavní autoři: Avezov, Edward, Cross, Benedict C.S., Kaminski Schierle, Gabriele S., Winters, Mikael, Harding, Heather P., Melo, Eduardo Pinho, Kaminski, Clemens F., Ron, David
Médium: Artigo
Jazyk:Inglês
Vydáno: The Rockefeller University Press 2013
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3628511/
https://ncbi.nlm.nih.gov/pubmed/23589496
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201211155
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