Reduced contribution of thermally labile sugar lesions to DNA double strand break formation after exposure to heavy ions

In cells exposed to low linear energy transfer (LET) ionizing-radiation (IR), double-strand-breaks (DSBs) form within clustered-damage-sites (CDSs) from lesions disrupting the DNA sugar-phosphate backbone. It is commonly assumed that all DSBs form promptly and are immediately detected by the cellula...

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Main Authors: Singh, Satyendra K, Bencsik-Theilen, Alena, Mladenov, Emil, Jakob, Burkhard, Taucher-Scholz, Gisela, Iliakis, George
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2013
Assuntos:
Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3627621/
https://ncbi.nlm.nih.gov/pubmed/23547740
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1748-717X-8-77
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