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3D-QSAR-Assisted Design, Synthesis, and Evaluation of Novobiocin Analogues

[Image: see text] Hsp90 is an attractive therapeutic target for the treatment of cancer. Extensive structural modifications to novobiocin, the first Hsp90 C-terminal inhibitor discovered, have produced a library of novobiocin analogues and revealed some structure–activity relationships. On the basis...

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Bibliografiske detaljer
Main Authors: Zhao, Huiping, Moroni, Elisabetta, Yan, Bin, Colombo, Giorgio, Blagg, Brian S. J.
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2012
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3627542/
https://ncbi.nlm.nih.gov/pubmed/23606927
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml300275g
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