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3D-QSAR-Assisted Design, Synthesis, and Evaluation of Novobiocin Analogues
[Image: see text] Hsp90 is an attractive therapeutic target for the treatment of cancer. Extensive structural modifications to novobiocin, the first Hsp90 C-terminal inhibitor discovered, have produced a library of novobiocin analogues and revealed some structure–activity relationships. On the basis...
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| Auteurs principaux: | , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American
Chemical Society
2012
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| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3627542/ https://ncbi.nlm.nih.gov/pubmed/23606927 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml300275g |
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