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Synthesis and Evaluation of Noviose Replacements on Novobiocin That Manifest Antiproliferative Activity
[Image: see text] Structural modifications to the coumarin core and benzamide side chain of novobiocin have successfully transformed the natural product from a selective DNA gyrase inhibitor into a potent inhibitor of the Hsp90 C-terminus. However, no structure−activity relationship studies have bee...
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| 主要な著者: | , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Chemical Society
2010
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| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3167089/ https://ncbi.nlm.nih.gov/pubmed/21904660 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml100070r |
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