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Synthesis and Evaluation of Noviose Replacements on Novobiocin That Manifest Antiproliferative Activity

[Image: see text] Structural modifications to the coumarin core and benzamide side chain of novobiocin have successfully transformed the natural product from a selective DNA gyrase inhibitor into a potent inhibitor of the Hsp90 C-terminus. However, no structure−activity relationship studies have bee...

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Hlavní autoři: Zhao, Huiping, Reddy Kusuma, Bhaskar, Blagg, Brian S. J.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Chemical Society 2010
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3167089/
https://ncbi.nlm.nih.gov/pubmed/21904660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml100070r
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