CONSTITUTIVE ACTIVATION OF A(3) ADENOSINE RECEPTORS BY SITE-DIRECTED MUTAGENESIS

The objective of this study was to create constitutively active mutant human A(3) adenosine receptors (ARs) using single amino acid replacements, based on findings from other G protein-coupled receptors. A(3) ARs mutated in transmembrane helical domains (TMs) 1, 3, 6, and 7 were expressed in COS-7 c...

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Main Authors: Chen, Aishe, Gao, Zhan-Guo, Barak, Dov, Liang, Bruce T., Jacobson, Kenneth A.
Formato: Artigo
Idioma:Inglês
Publicado: 2001
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3626079/
https://ncbi.nlm.nih.gov/pubmed/11396942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1006/bbrc.2001.5027
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