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Quantitative encoding of a partial agonist effect on individual opioid receptors by multi-site phosphorylation and threshold detection

Many drugs act as partial agonists of seven-transmembrane signaling receptors when compared to endogenous ligands. Partial agonism is well described as a 'macroscopic' property manifest at the level of physiological systems or cell populations, but it is not known whether partial agonists...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Lau, Elaine K., Trester-Zedlitz, Michelle, Trinidad, Jonathan C., Kotowski, Sarah J., Krutchinsky, Andrew N., Burlingame, Alma L., von Zastrow, Mark
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: 2011
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC3625704/
https://ncbi.nlm.nih.gov/pubmed/21868358
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2001748
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