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History and development of mixed opioid agonists, partial agonists and antagonists
1 A brief history of the development of narcotic antagonists is outlined. 2 The clinical and pharmacological observations leading to the discovery of dualism of opiate receptors are reviewed. 3 An extension of this theory to a three-receptor model (μ, χ and σ) is required to rationalize the pharmaco...
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
1979
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1429308/ https://ncbi.nlm.nih.gov/pubmed/380616 |
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