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Quantitative encoding of a partial agonist effect on individual opioid receptors by multi-site phosphorylation and threshold detection
Many drugs act as partial agonists of seven-transmembrane signaling receptors when compared to endogenous ligands. Partial agonism is well described as a 'macroscopic' property manifest at the level of physiological systems or cell populations, but it is not known whether partial agonists...
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| Hauptverfasser: | , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2011
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3625704/ https://ncbi.nlm.nih.gov/pubmed/21868358 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2001748 |
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