Polymorphisms of the Kappa Opioid Receptor and Prodynorphin Genes: HIV risk and HIV Natural History

OBJECTIVE: Studies indicate cross-desensitization between opioid receptors (e.g., kappa opioid receptor, OPRK1), and chemokine receptors (e.g., CXCR4) involved in HIV infection. We tested whether gene variants of OPRK1 and its ligand, prodynorphin (PDYN), influence the outcome of HIV therapy. METHOD...

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Main Authors: Proudnikov, Dmitri, Randesi, Matthew, Levran, Orna, Yuferov, Vadim, Crystal, Howard, Ho, Ann, Ott, Jurg, Kreek, Mary Jeanne
格式: Artigo
語言:Inglês
出版: 2013
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3625517/
https://ncbi.nlm.nih.gov/pubmed/23392455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/QAI.0b013e318285cd0c
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