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Association of variants of prodynorphin promoter 68-bp repeats in Caucasians with opioid dependence diagnosis: Effect on age trajectory of heroin use

The dynorphin/kappa opioid receptor (Dyn/KOR) system is involved in reward processing and dysphoria/anhedonia. Exposure to mu-opioid receptor agonists such as heroin increases expression of the prodynorphin gene (PDYN) in the brain. In this study in a Caucasian cohort, we examined the association of...

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Detalhes bibliográficos
Publicado no:Neurosci Lett
Main Authors: Yuferov, Vadim, Randesi, Matthew, Butelman, Eduardo R, van den Brink, Wim, Blanken, Peter, van Ree, Jan M, Ott, Jürg, Kreek, Mary Jeanne
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6594859/
https://ncbi.nlm.nih.gov/pubmed/30936032
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neulet.2019.03.038
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