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Polymorphisms of the Kappa Opioid Receptor and Prodynorphin Genes: HIV risk and HIV Natural History

OBJECTIVE: Studies indicate cross-desensitization between opioid receptors (e.g., kappa opioid receptor, OPRK1), and chemokine receptors (e.g., CXCR4) involved in HIV infection. We tested whether gene variants of OPRK1 and its ligand, prodynorphin (PDYN), influence the outcome of HIV therapy. METHOD...

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Detalhes bibliográficos
Main Authors: Proudnikov, Dmitri, Randesi, Matthew, Levran, Orna, Yuferov, Vadim, Crystal, Howard, Ho, Ann, Ott, Jurg, Kreek, Mary Jeanne
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3625517/
https://ncbi.nlm.nih.gov/pubmed/23392455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/QAI.0b013e318285cd0c
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