Polymorphisms of the Kappa Opioid Receptor and Prodynorphin Genes: HIV risk and HIV Natural History

OBJECTIVE: Studies indicate cross-desensitization between opioid receptors (e.g., kappa opioid receptor, OPRK1), and chemokine receptors (e.g., CXCR4) involved in HIV infection. We tested whether gene variants of OPRK1 and its ligand, prodynorphin (PDYN), influence the outcome of HIV therapy. METHOD...

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Hlavní autoři: Proudnikov, Dmitri, Randesi, Matthew, Levran, Orna, Yuferov, Vadim, Crystal, Howard, Ho, Ann, Ott, Jurg, Kreek, Mary Jeanne
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3625517/
https://ncbi.nlm.nih.gov/pubmed/23392455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/QAI.0b013e318285cd0c
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