Angiotensin 1-7 and Mas decrease thrombosis in Bdkrb2(−/−) mice by increasing NO and prostacyclin to reduce platelet spreading and glycoprotein VI activation

Bradykinin B2 receptor–deleted mice (Bdkrb2(−/−)) have delayed carotid artery thrombosis times and prolonged tail bleeding time resulting from elevated angiotensin II (AngII) and angiotensin receptor 2 (AT2R) producing increased plasma nitric oxide (NO) and prostacyclin. Bdkrb2(−/−) also have elevat...

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Autori principali: Fang, Chao, Stavrou, Evi, Schmaier, Alec A., Grobe, Nadja, Morris, Mariana, Chen, Andrew, Nieman, Marvin T., Adams, Gregory N., LaRusch, Gretchen, Zhou, Yihua, Bilodeau, Matthew L., Mahdi, Fakhri, Warnock, Mark, Schmaier, Alvin H.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2013
Soggetti:
Thrombosis and Hemostasis
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3624945/
https://ncbi.nlm.nih.gov/pubmed/23386129
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-09-459156
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