miR-21 mediates hematopoietic suppression in MDS by activating TGF-β signaling

Myelodysplastic syndromes (MDS) are characterized by ineffective hematopoiesis that leads to peripheral cytopenias. We observed that SMAD7, a negative regulator of transforming growth factor–beta (TGF-β) receptor-I kinase, is markedly reduced in MDS and leads to ineffective hematopoiesis by overacti...

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Main Authors: Bhagat, Tushar D., Zhou, Li, Sokol, Lubomir, Kessel, Rachel, Caceres, Gisela, Gundabolu, Krishna, Tamari, Roni, Gordon, Shanisha, Mantzaris, Ioannis, Jodlowski, Tomasz, Yu, Yiting, Jing, Xiaohong, Polineni, Rahul, Bhatia, Kavi, Pellagatti, Andrea, Boultwood, Jacqueline, Kambhampati, Suman, Steidl, Ulrich, Stein, Cy, Ju, Wenjun, Liu, Gang, Kenny, Paraic, List, Alan, Bitzer, Markus, Verma, Amit
Formato: Artigo
Idioma:Inglês
Publicado: American Society of Hematology 2013
Assuntos:
Hematopoiesis and Stem Cells
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3624935/
https://ncbi.nlm.nih.gov/pubmed/23390194
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-12-397067
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