Inhibition of the TGF-β receptor I kinase promotes hematopoiesis in MDS

MDS is characterized by ineffective hematopoiesis that leads to peripheral cytopenias. Development of effective treatments has been impeded by limited insight into pathogenic pathways governing dysplastic growth of hematopoietic progenitors. We demonstrate that smad2, a downstream mediator of transf...

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Detalhes bibliográficos
Main Authors: Zhou, Li, Nguyen, Aaron N., Sohal, Davendra, Ying Ma, Jing, Pahanish, Perry, Gundabolu, Krishna, Hayman, Josh, Chubak, Adam, Mo, Yongkai, Bhagat, Tushar D., Das, Bhaskar, Kapoun, Ann M., Navas, Tony A., Parmar, Simrit, Kambhampati, Suman, Pellagatti, Andrea, Braunchweig, Ira, Zhang, Ying, Wickrema, Amittha, Medicherla, Satyanarayana, Boultwood, Jacqueline, Platanias, Leonidas C., Higgins, Linda S., List, Alan F., Bitzer, Markus, Verma, Amit
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2008
Assuntos:
Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2569182/
https://ncbi.nlm.nih.gov/pubmed/18474728
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-02-139824
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