Prostasin Is Required for Matriptase Activation in Intestinal Epithelial Cells to Regulate Closure of the Paracellular Pathway

The type II transmembrane serine protease matriptase is a key regulator of epithelial barriers in skin and intestine. In skin, matriptase acts upstream of the glycosylphosphatidylinositol-anchored serine protease, prostasin, to activate the prostasin zymogen and initiate a proteolytic cascade that i...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijät: Buzza, Marguerite S., Martin, Erik W., Driesbaugh, Kathryn H., Désilets, Antoine, Leduc, Richard, Antalis, Toni M.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Biochemistry and Molecular Biology 2013
Aiheet:
Enzymology
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3624416/
https://ncbi.nlm.nih.gov/pubmed/23443662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.443432
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