Inflammatory cytokines down-regulate the barrier-protective prostasin-matriptase proteolytic cascade early in experimental colitis

Compromised gastrointestinal barrier function is strongly associated with the progressive and destructive pathologies of the two main forms of irritable bowel disease (IBD), ulcerative colitis (UC), and Crohn's disease (CD). Matriptase is a membrane-anchored serine protease encoded by suppressi...

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Dades bibliogràfiques
Publicat a:J Biol Chem
Autors principals: Buzza, Marguerite S., Johnson, Tierra A., Conway, Gregory D., Martin, Erik W., Mukhopadhyay, Subhradip, Shea-Donohue, Terez, Antalis, Toni M.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2017
Matèries:
Molecular Bases of Disease
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5491767/
https://ncbi.nlm.nih.gov/pubmed/28490634
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.771469
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