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Targeting zymogen activation to control the matriptase-prostasin proteolytic cascade

Membrane-associated serine protease matriptase has been implicated in human diseases, and might be a drug target. In the present study, a novel class of matriptase inhibitors targeting zymogen activation is developed by a combination of the screening of compound library using a cell-based matriptase...

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Autores principales: Xu, Zhenghong, Chen, Ya-Wen, Battu, Aruna, Wilder, Paul, Weber, David, Yu, Wenbo, MacKerell, Alexander D., Chen, Li-Mei, Chai, Karl X., Johnson, Michael D., Lin, Chen-Yong
Formato: Artigo
Lenguaje:Inglês
Publicado: 2011
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3214968/
https://ncbi.nlm.nih.gov/pubmed/21966950
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm200920s
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