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Targeting zymogen activation to control the matriptase-prostasin proteolytic cascade
Membrane-associated serine protease matriptase has been implicated in human diseases, and might be a drug target. In the present study, a novel class of matriptase inhibitors targeting zymogen activation is developed by a combination of the screening of compound library using a cell-based matriptase...
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| Main Authors: | , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3214968/ https://ncbi.nlm.nih.gov/pubmed/21966950 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm200920s |
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