Timeless-Dependent DNA Replication-Coupled Recombination Promotes Kaposi's Sarcoma-Associated Herpesvirus Episome Maintenance and Terminal Repeat Stability

Kaposi's Sarcoma-associated herpesvirus (KSHV) is maintained as a stable episome in latently infected pleural effusion lymphoma (PEL) cells. Episome maintenance is conferred by the binding of the KSHV-encoded LANA protein to the viral terminal repeats (TR). Here, we show that DNA replication in...

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Main Authors: Dheekollu, Jayaraju, Chen, Horng-Shen, Kaye, Kenneth M., Lieberman, Paul M.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2013
Teme:
Genome Replication and Regulation of Viral Gene Expression
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3624199/
https://ncbi.nlm.nih.gov/pubmed/23325691
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02211-12
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