Role of Kaposi's Sarcoma-Associated Herpesvirus C-Terminal LANA Chromosome Binding in Episome Persistence

Kaposi's sarcoma-associated herpesvirus (KSHV) LANA is an 1,162-amino-acid protein that tethers terminal repeat (TR) DNA to mitotic chromosomes to mediate episome persistence in dividing cells. C-terminal LANA self-associates to bind TR DNA. LANA contains independent N- and C-terminal chromosom...

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Detalhes bibliográficos
Main Authors: Kelley-Clarke, Brenna, De Leon-Vazquez, Erika, Slain, Katherine, Barbera, Andrew J., Kaye, Kenneth M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2009
Assuntos:
Genome Replication and Regulation of Viral Gene Expression
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2668501/
https://ncbi.nlm.nih.gov/pubmed/19225000
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02395-08
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