Oppositional Regulation of Noxa by JNK1 and JNK2 during Apoptosis Induced by Proteasomal Inhibitors

Proteasome inhibitors (PIs) potently induce apoptosis in a variety of tumor cells, but the underlying mechanisms are not fully elucidated. Comparing PI-induced apoptosis susceptibilities of various mouse embryonic fibroblast (MEF) lines differing in their c-jun N-terminal kinase (JNK) 1 and 2 status...

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Detalhes bibliográficos
Principais autores: Pietkiewicz, Sabine, Sohn, Dennis, Piekorz, Roland P., Grether-Beck, Susanne, Budach, Wilfried, Sabapathy, Kanaga, Jänicke, Reiner U.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3623862/
https://ncbi.nlm.nih.gov/pubmed/23593480
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0061438
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