Noxa Mediates Hepatic Stellate Cell Apoptosis by Proteasome Inhibition

AIM: Induction of hepatic stellate cell (HSC) apoptosis is a viable therapeutic strategy to reduce liver fibrogenesis. Although BH3-only proteins of the Bcl-2 family trigger pro-apoptotic pathways, the BH3-only proteins mediating HSC apoptosis have not been well defined. Our aim, using proteasome in...

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Détails bibliographiques
Auteurs principaux: Sosa Seda, Ivette M., Mott, Justin L., Akazawa, Yuko, Barreyro, Fernando J., Bronk, Steven F., Kaufmann, Scott H., Gores, Gregory J.
Format: Artigo
Langue:Inglês
Publié: 2010
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2922948/
https://ncbi.nlm.nih.gov/pubmed/20557369
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1872-034X.2010.00668.x
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