The Proteasome Is Required for Rapid Initiation of Death Receptor-Induced Apoptosis

Due to their tremendous apoptosis-inducing potential, proteasomal inhibitors (PIs) have recently entered clinical trials. Here we show, however, that various PIs rescued proliferating tumor cells from death receptor-induced apoptosis. This protection correlated with the stabilization of X-linked IAP...

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Detalhes bibliográficos
Main Authors: Sohn, Dennis, Totzke, Gudrun, Essmann, Frank, Schulze-Osthoff, Klaus, Levkau, Bodo, Jänicke, Reiner U.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2006
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1430261/
https://ncbi.nlm.nih.gov/pubmed/16479014
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.26.5.1967-1978.2006
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