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The NTD-CTD intersubunit interface plays a critical role in assembly and stabilization of the HIV-1 capsid

BACKGROUND: Lentiviruses exhibit a cone-shaped capsid composed of subunits of the viral CA protein. The intrinsic stability of the capsid is critical for HIV-1 infection, since both stabilizing and destabilizing mutations compromise viral infectivity. Structural studies have identified three intersu...

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Autori principali: Yufenyuy, Ernest L, Aiken, Christopher
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2013
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3623829/
https://ncbi.nlm.nih.gov/pubmed/23497318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-4690-10-29
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