Protease Cleavage Leads to Formation of Mature Trimer Interface in HIV-1 Capsid

During retrovirus particle maturation, the assembled Gag polyprotein is cleaved by the viral protease into matrix (MA), capsid (CA), and nucleocapsid (NC) proteins. To form the mature viral capsid, CA rearranges, resulting in a lattice composed of hexameric and pentameric CA units. Recent structural...

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Main Authors: Meng, Xin, Zhao, Gongpu, Yufenyuy, Ernest, Ke, Danxia, Ning, Jiying, DeLucia, Maria, Ahn, Jinwoo, Gronenborn, Angela M., Aiken, Christopher, Zhang, Peijun
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2012
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3426514/
https://ncbi.nlm.nih.gov/pubmed/22927821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1002886
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