Sulfhydration mediates neuroprotective actions of parkin

Increases in S-nitrosylation and inactivation of the neuroprotective ubiquitin E3 ligase, parkin, in the brains of patients with Parkinson’s Disease (PD) are thought to be pathogenic and suggest a possible mechanism linking parkin to sporadic PD. Here we demonstrate that physiologic modification of...

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Hoofdauteurs: Vandiver, M. Scott, Paul, Bindu D., Xu, Risheng, Karuppagounder, Senthilkumar, Rao, Feng, Snowman, Adele M., Ko, Han Seok, Lee, Yun Il, Dawson, Valina L., Dawson, Ted M., Sen, Nilkantha, Snyder, Solomon H.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2013
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3622945/
https://ncbi.nlm.nih.gov/pubmed/23535647
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms2623
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