The c-Abl inhibitor, Nilotinib, protects dopaminergic neurons in a preclinical animal model of Parkinson's disease

Por Karuppagounder, Senthilkumar S., Brahmachari, Saurav, Lee, Yunjong, Dawson, Valina L., Dawson, Ted M., Ko, Han Seok
Publicado em 2014

MicroRNA-132 dysregulation in Toxoplasma gondii infection has implications for dopamine signaling pathway

Por Xiao, Jianchun, Li, Ye, Prandovszky, Emese, Karuppagounder, Senthilkumar S., Talbot, C. Conover, Dawson, Valina L., Dawson, Ted M., Yolken, Robert H.
Publicado em 2014

Proneural Transcription Factor Atoh1 Drives Highly Efficient Differentiation of Human Pluripotent Stem Cells Into Dopaminergic Neurons

Por Sagal, Jonathan, Zhan, Xiping, Xu, Jinchong, Tilghman, Jessica, Karuppagounder, Senthilkumar S., Chen, Li, Dawson, Valina L., Dawson, Ted M., Laterra, John, Ying, Mingyao
Publicado em 2014

Genetic deficiency of the mitochondrial protein PGAM5 causes a Parkinson’s-like movement disorder

Por Lu, Wei, Karuppagounder, Senthilkumar S., Springer, Danielle A., Allen, Michele D., Zheng, Lixin, Chao, Brittany, Zhang, Yan, Dawson, Valina L., Dawson, Ted M., Lenardo, Michael
Publicado no Nat Commun (2014)

Poly(ADP-ribose) polymerase-dependent energy depletion occurs through inhibition of glycolysis

Por Andrabi, Shaida A., Umanah, George K. E., Chang, Calvin, Stevens, Daniel A., Karuppagounder, Senthilkumar S., Gagné, Jean-Philippe, Poirier, Guy G., Dawson, Valina L., Dawson, Ted M.
Publicado em 2014

Phosphorylation by the c-Abl protein tyrosine kinase inhibits parkin's ubiquitination and protective function

Por Ko, Han Seok, Lee, Yunjong, Shin, Joo-Ho, Karuppagounder, Senthilkumar S., Gadad, Bharathi Shrikanth, Koleske, Anthony J., Pletnikova, Olga, Troncoso, Juan C., Dawson, Valina L., Dawson, Ted M.
Publicado em 2010

Sulfhydration mediates neuroprotective actions of parkin

Por Vandiver, M. Scott, Paul, Bindu D., Xu, Risheng, Karuppagounder, Senthilkumar, Rao, Feng, Snowman, Adele M., Ko, Han Seok, Lee, Yun Il, Dawson, Valina L., Dawson, Ted M., Sen, Nilkantha, Snyder, Solomon H.
Publicado em 2013

LRRK2 G2019S Transgenic Mice Display Increased Susceptibility to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-Mediated Neurotoxicity

Por Karuppagounder, Senthilkumar S., Xiong, Yulan, Lee, Yunjong, Lawless, Maeve C., Kim, Donghyun, Nordquist, Emily, Martin, Ian, Ge, Preston, Brahmachari, Saurav, Jhaldiyal, Aanishaa, kumar, Manoj, Andrabi, Shaida A., Dawson, Ted M., Dawson, Valina L.
Publicado no J Chem Neuroanat (2016)

Overexpression of Parkinson’s Disease-Associated Mutation LRRK2 G2019S in Mouse Forebrain Induces Behavioral Deficits and α-Synuclein Pathology

Por Xiong, Yulan, Neifert, Stewart, Karuppagounder, Senthilkumar S., Stankowski, Jeannette N., Lee, Byoung Dae, Grima, Jonathan C., Chen, Guanxing, Ko, Han Seok, Lee, Yunjong, Swing, Debbie, Tessarollo, Lino, Dawson, Ted M., Dawson, Valina L.
Publicado no eNeuro (2017)

Activation of tyrosine kinase c-Abl contributes to α-synuclein–induced neurodegeneration

Por Brahmachari, Saurav, Ge, Preston, Lee, Su Hyun, Kim, Donghoon, Karuppagounder, Senthilkumar S., Kumar, Manoj, Mao, Xiaobo, Shin, Joo Ho, Lee, Yunjong, Pletnikova, Olga, Troncoso, Juan C., Dawson, Valina L., Dawson, Ted M., Ko, Han Seok
Publicado no J Clin Invest (2016)

Parthanatos Mediates AIMP2 Activated Age Dependent Dopaminergic Neuronal Loss

Por Lee, Yunjong, Karuppagounder, Senthilkumar S., Shin, Joo-Ho, Lee, Yun-Il, Ko, Han Seok, Swing, Debbie, Jiang, Haisong, Kang, Sung-Ung, Lee, Byoung Dae, Kang, Ho Chul, Kim, Donghoon, Tessarollo, Lino, Dawson, Valina L., Dawson, Ted M.
Publicado em 2013

Adult Conditional Knockout of PGC-1α Leads to Loss of Dopamine Neurons

Por Jiang, Haisong, Kang, Sung-Ung, Zhang, Shuran, Karuppagounder, Senthilkumar, Xu, Jinchong, Lee, Yong-Kyu, Kang, Bong-Gu, Lee, Yunjong, Zhang, Jianmin, Pletnikova, Olga, Troncoso, Juan C., Pirooznia, Shelia, Andrabi, Shaida A., Dawson, Valina L., Dawson, Ted M.
Publicado no eNeuro (2016)