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Hydrogen sulfide-linked sulfhydration of NF-κB mediates its anti-apoptotic actions
Nuclear factor κB (NF-κB) is an anti-apoptotic transcription factor. We show that the anti-apoptotic actions of NF-κB are mediated by hydrogen sulfide (H(2)S) synthesized by cystathionine gamma-lyase (CSE). TNFα treatment triples H(2)S generation by stimulating binding of SP1 to the CSE promoter. H(...
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| Hoofdauteurs: | , , , , , , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
2012
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3261430/ https://ncbi.nlm.nih.gov/pubmed/22244329 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2011.10.021 |
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