NADPH oxidase inhibition prevents beta cell dysfunction induced by prolonged elevation of oleate in rodents

AIMS/HYPOTHESIS: The activation of NADPH oxidase has been implicated in NEFA-induced beta cell dysfunction. However, the causal role of this activation in vivo remains unclear. Here, using rodents, we investigated whether pharmacological or genetic inhibition of NADPH oxidase could prevent NEFA-indu...

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Main Authors: Koulajian, K., Desai, T., Liu, G. C., Ivovic, A., Patterson, J. N., Tang, C., El-Benna, J., Joseph, J. W., Scholey, J. W., Giacca, A.
Formato: Artigo
Idioma:Inglês
Publicado: Springer-Verlag 2013
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3622749/
https://ncbi.nlm.nih.gov/pubmed/23429921
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00125-013-2858-4
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